2,4,6-triiodo-5-substituted-amino-isophthalate esters useful as x-ray contrast agents for medical diagnostics imaging

• Main Authors: ESTEP; KIMBERLY G, BACON; EDWARD R, DAUM; SOL J
• Format: Patent
• Language: English
• Published: 23.09.1997
• Edition: 6
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

Compounds having the structure: wherein Q is n is an integer from 0 to 20; R1 is H, alkyl, fluoroalkyl, cycloalkyl, aryl, aralkyl, alkoxyalkyl or acetamidoalkyl; R2, R3, R4 and R5 are independently H, alkyl, fluoroalkyl, halogen, hydroxy, acylamino, acetamidoalkyl, cyano, sulfonyl, carboxamido or sulfonamido; R6 is alkyl, cycloalkyl, aryl, or aralkyl; and R7 is H or -COR6 are useful as contrast agents in medical diagnostic x-ray imaging compositions and methods. Compounds having the structure: wherein Q is n is an integer from 0 to 20; R1 is H, alkyl, fluoroalkyl, cycloalkyl, aryl, aralkyl, alkoxyalkyl or acetamidoalkyl; R2, R3, R4 and R5 are independently H, alkyl, fluoroalkyl, halogen, hydroxy, acylamino, acetamidoalkyl, cyano, sulfonyl, carboxamido or sulfonamido; R6 is alkyl, cycloalkyl, aryl, or aralkyl; and R7 is H or -COR6 are useful as contrast agents in medical diagnostic x-ray imaging compositions and methods.