Intermediates for the preparation of 1,3,dihydro-2H-imidazo[4,5-B]quinolin-2-one derivatives

• Main Authors: DE CHAFFOY DE COURCELLES; DIDIER R. G. G, RAEYMAEKERS; ALFONS H. M, FREYNE; EDDY J. E
• Format: Patent
• Language: English
• Published: 30.07.1996
• Edition: 6
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention relates to compounds of the formula (IV) wherein R represents hydrogen; C1-6alkyl; C3-6cycloalkyl; phenyl optionally substituted with from 1 to 3 substituents each independently selected from halo, hydroxy, C1-6alkyloxy, C5-6cycloalkyloxy, C1-6alkyl or trifluoromethyl; pyridinyl; or thienyl optionally substituted with halo or C1-6alkyl; and =C=X is a radical of the formula: =C=O (a), =C=N-O-R1 (b), or =C=CH-R2 (c); the addition salts thereof and stereochemically isomeric forms thereof, said compounds being useful as intermediate to potent inhibitors of both phosphodiesterase III and IV, which are useful in the treatment of warm-blooded animals suffering from allergic disorders, atopic diseases and related afflications. The present invention relates to compounds of the formula (IV) wherein R represents hydrogen; C1-6alkyl; C3-6cycloalkyl; phenyl optionally substituted with from 1 to 3 substituents each independently selected from halo, hydroxy, C1-6alkyloxy, C5-6cycloalkyloxy, C1-6alkyl or trifluoromethyl; pyridinyl; or thienyl optionally substituted with halo or C1-6alkyl; and =C=X is a radical of the formula: =C=O (a), =C=N-O-R1 (b), or =C=CH-R2 (c); the addition salts thereof and stereochemically isomeric forms thereof, said compounds being useful as intermediate to potent inhibitors of both phosphodiesterase III and IV, which are useful in the treatment of warm-blooded animals suffering from allergic disorders, atopic diseases and related afflications.