Human leukocyte elastase (HLE) inhibitors, and related pharmaceutical compositions and methods of use

• Main Authors: HIEBERT; CHARLES K, LAIBELMAN; ALAN, RYAN; KENNETH J
• Format: Patent
• Language: English
• Published: 27.06.1995
• Edition: 6
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Novel therapeutic agents useful as inhibitors of HLE are provided. The compounds have the structural formula (I) (I) wherein R1 through R9, m, n and p are as defined herein. Methods of using the compounds of formula (I) to inhibit serine proteases and to treat physiological conditions and disease st...