Aryl alkenoic acid derivatives as leukotriene antagonists

Aryl alkenoic acid derivatives, and physiologically acceptable salts thereof, are provided which are potent leukotriene antagonists and may be used for the treatment of circulatory diseases and preferably for respiratory diseases such as asthma. The derivatives have a general formula I (I) in which...

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Main Authors SCHUT; ROBERT N, ROSENTRETER; ULRICH, KLUENDER; HAROLD C, NORMAN; PETER, ABRAM; TREVOR S, TUDHOPE; STEPHEN R, MEIER; HEINRICH
Format Patent
LanguageEnglish
Published 30.11.1993
Edition5
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Abstract Aryl alkenoic acid derivatives, and physiologically acceptable salts thereof, are provided which are potent leukotriene antagonists and may be used for the treatment of circulatory diseases and preferably for respiratory diseases such as asthma. The derivatives have a general formula I (I) in which X is -S-, W is CH=CH; o is 1 to 4; n is 2 to 6; m is 0 to 2; T and Z, same or different, represent oxygen or a direct bond; R2 and R3, represent hydrogen, or fluorine; A represents carboxyl, CO2R44, wherein R4 is lower alkyl R is wherein Y represents carboxyl, CO2R4, wherein R4 is lower alkyl R7 and R8, same or different, represent H or lower alkyl; R9 represents -OH, -O-alkyl, NH2 or a NHCH2CO2H group; and R10 R3 is H.
AbstractList Aryl alkenoic acid derivatives, and physiologically acceptable salts thereof, are provided which are potent leukotriene antagonists and may be used for the treatment of circulatory diseases and preferably for respiratory diseases such as asthma. The derivatives have a general formula I (I) in which X is -S-, W is CH=CH; o is 1 to 4; n is 2 to 6; m is 0 to 2; T and Z, same or different, represent oxygen or a direct bond; R2 and R3, represent hydrogen, or fluorine; A represents carboxyl, CO2R44, wherein R4 is lower alkyl R is wherein Y represents carboxyl, CO2R4, wherein R4 is lower alkyl R7 and R8, same or different, represent H or lower alkyl; R9 represents -OH, -O-alkyl, NH2 or a NHCH2CO2H group; and R10 R3 is H.
Author ROSENTRETER; ULRICH
SCHUT; ROBERT N
MEIER; HEINRICH
NORMAN; PETER
KLUENDER; HAROLD C
ABRAM; TREVOR S
TUDHOPE; STEPHEN R
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– fullname: ABRAM; TREVOR S
– fullname: TUDHOPE; STEPHEN R
– fullname: MEIER; HEINRICH
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Snippet Aryl alkenoic acid derivatives, and physiologically acceptable salts thereof, are provided which are potent leukotriene antagonists and may be used for the...
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CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
Title Aryl alkenoic acid derivatives as leukotriene antagonists
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