IMIDAZOLE-CONTAINING PEPTIDES HAVING IMMUNOMODULATORY ACTIVITY

• Main Authors: MATSUMOTO; KAZUO, TAKATA; ISAO, HAYASHI; KIMIAKI, SATO; TADASHI, NUNAMI; KENICHI
• Format: Patent
• Language: English
• Published: 13.04.1993
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Imidazole-containing peptide of the formula: wherein R is a branched alkyl group, a branched alkyloxy group or an aryl-substituted lower alkyloxy group, R and R are the same or different and each is hydrogen atom or a lower alkyl group, R and R are a phenyl-substituted lower alkyl group, R is hydrogen atom or a lower alkoxycarbonyl group, R is hydrogen atom or a nitrogen-containing heterocyclic group-substituted lower alkylthio group, X and X are the same or different and each is - @H-, -O@H- or - @-, A is a lower alkylene group which may be substituted with a substituent selected from the group consisting of a lower alkoxy group, hydroxymethyl group and a group of the formula: and R and R are the same or different and each is hydrogen atom or a lower group, or a pharmaceutically acceptable salt thereof, which is useful as an immunomodulator and as an agent for the treatment and/or prophylaxis of autoimmune diseases such as rheumatoid arthritis, mulripule sclerosis, systemic lupus erthematodes, glomerulonephris,rhumatic fever or type I diabetes and atopic allergy, a processes for the preparation thereof, and a pharmaceutical composition containing said compound as an active ingredient.