7-({60 -SULFOACYLAMIDO)CEPHALOSPORANIC ACIDS

Novel cephalosporanic acid derivatives which are active against both Gram positive and Gram negative pathogenic bacteria, particularly Pseudomonas, and which have an alpha -sulfoacylamino group at 7-position. A few examples of the compounds are 7-( alpha -sulfophenylacetamido)-cephalosporanic acid,...

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Bibliographic Details
Main Authors NOMURA; HIROAKI, ISHIGURO; TOSHIHIRO, FUGONO; TAKESHI
Format Patent
LanguageEnglish
Published 26.10.1976
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:Novel cephalosporanic acid derivatives which are active against both Gram positive and Gram negative pathogenic bacteria, particularly Pseudomonas, and which have an alpha -sulfoacylamino group at 7-position. A few examples of the compounds are 7-( alpha -sulfophenylacetamido)-cephalosporanic acid, 7-( alpha -sulfopropionamido)-cephalosporanic acid, 7-( alpha -sulfocapronamido)-cephalosporanic acid. They are prepared by condensing 7-aminocephalosporanic acid or salts thereof with alpha -sulfocarboxylic acid or functional derivatives thereof in the presence of a solvent at -2 DEG - 10 DEG C.
Bibliography:Application Number: US19750547169