Process for preparing 2{40 ,3{40 ,5{40 -tri-0-acetyl-6-azauridine

Process for preparing 2',3',5'-tri-0-acetyl-6-azauridine having the following formula WHICH COMPRISES REACTING A CRUDE ANOMERIC MIXTURE OF METHYL D-ribofuranosides having the formula WITH ANHYDROUS HYDROGEN CHLORIDE OR ANHYDROUS HYDROGEN BROMIDE IN THE PRESENCE OF ACETIC ANHYDRIDE AND...

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Bibliographic Details
Main Authors SORM; FRANTISEK, PISKALA; ALOIS
Format Patent
LanguageEnglish
Published 04.05.1976
Subjects
CHEMISTRY
DERIVATIVES THEREOF
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
SUGARS
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Summary:Process for preparing 2',3',5'-tri-0-acetyl-6-azauridine having the following formula WHICH COMPRISES REACTING A CRUDE ANOMERIC MIXTURE OF METHYL D-ribofuranosides having the formula WITH ANHYDROUS HYDROGEN CHLORIDE OR ANHYDROUS HYDROGEN BROMIDE IN THE PRESENCE OF ACETIC ANHYDRIDE AND ACETIC ACID TO THEREBY FORM THE CORRESPONDING 2,3,5-TRI-0-ACETYL-D-ribofuranosyl halide having the formula WHEREIN X is chloro or bromo, reacting the halide of formula III with 3,5-bis-trimethylsilyloxy-1,2,4-triazine having the following formula IN THE PRESENCE OF AN INERT SOLVENT AND A MERCURIC HALIDE AND RECOVERING THE 2',3',5'-TRI-0-ACETYL-6-AZAURIDINE.
Bibliography:Application Number: US19740476459