SYSTEMS AND METHODS TO IDENTIFY MHC-ASSOCIATED ANTIGENS FOR THERAPEUTIC INTERVENTION

• Main Authors: LI, Juan, HALEY, Benjamin Joseph, GURUNG, Hem Raj, HEIDERSBACH, Amy Jeane, ROSE, Christopher Michael, CHAN, Pamela Pui Fung, TONG, Ann-Jay, BLANCHETTE, Craig, DARWISH, Martine Abraham
• Format: Patent
• Language: English
• Published: 22.08.2024
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; TESTING; VINEGAR; WINE

The present disclosure relates to compositions and methods of uses of a monoallelic MHC-expressing cell line, as well as method of identifying a neoepitope-MHIC binding pair and methods of treating a subject having a cancer or tumor expressing a neoantigen and a MHC allele.