IL15/IL15R ALPHA HETERODIMERIC FC-FUSION PROTEINS FOR THE EXPANSION OF NK CELLS IN THE TREATMENT OF SOLID TUMOURS

• Main Authors: Yadav, Rajbharan, Shivva, Vittal, Ungewickell, Alexander Joachim Paul, Sanjabi, Shomyseh
• Format: Patent
• Language: English
• Published: 04.07.2024
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present disclosure provides methods of treating cancer by administering a heterodimeric protein comprising a first monomer comprising an IL15 protein-Fc domain fusion and a second monomer comprising an IL15Rα protein-Fc domain fusion and either increasing the number of NK cells at least 20-fold...