OLIGONUCLEOTIDE AND NUCLEIC ACID SYNTHESIS
The present invention relates to methods for the high fidelity synthesis of oligonucleotides and polynucleotides on a solid surface. In particular, the invention relates to methods of synthesising oligonucleotides, polynucleotides, and doublestranded polynucleotides/nucleic acids, such as DNA and XN...
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Main Authors | , , , , , , , |
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Format | Patent |
Language | English |
Published |
20.06.2024
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Subjects | |
Online Access | Get full text |
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Summary: | The present invention relates to methods for the high fidelity synthesis of oligonucleotides and polynucleotides on a solid surface. In particular, the invention relates to methods of synthesising oligonucleotides, polynucleotides, and doublestranded polynucleotides/nucleic acids, such as DNA and XNA, wherein the process comprises thermally controlled deprotection steps at the 5′-OH of previously coupled nucleosides or nucleotides at selected sites on the surface of the substrate. |
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Bibliography: | Application Number: US202318353269 |