SPIROINDOLINE DERIVATIVE, AND PREPARATION METHOD AND MEDICAL USE THEREOF

A compound of Formula I, or a racemate, a racemate, a stereoisomer, a tautomer, an isotopically labeled compound, an N-oxide, a solvate, a polymorph, a metabolite, an ester, a prodrug or a pharmaceutically acceptable salt thereof are provided. Also provided is a pharmaceutical composition containing...

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Main Authors WANG, Guocheng, SONG, Yunlong, SHEN, Guangyuan, TENG, Guosheng, JIN, Lei, YAN, Hongbo, LIU, Peng, LIN, Daizong
Format Patent
LanguageEnglish
Published 13.06.2024
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Abstract A compound of Formula I, or a racemate, a racemate, a stereoisomer, a tautomer, an isotopically labeled compound, an N-oxide, a solvate, a polymorph, a metabolite, an ester, a prodrug or a pharmaceutically acceptable salt thereof are provided. Also provided is a pharmaceutical composition containing the compound of Formula I and derivatives, a preparation method therefor, and use thereof as a GHSR agonist in the preparation of drugs for diagnosing, preventing and/or treating growth hormone dependent disease. The structure of Formula I is shown below:
AbstractList A compound of Formula I, or a racemate, a racemate, a stereoisomer, a tautomer, an isotopically labeled compound, an N-oxide, a solvate, a polymorph, a metabolite, an ester, a prodrug or a pharmaceutically acceptable salt thereof are provided. Also provided is a pharmaceutical composition containing the compound of Formula I and derivatives, a preparation method therefor, and use thereof as a GHSR agonist in the preparation of drugs for diagnosing, preventing and/or treating growth hormone dependent disease. The structure of Formula I is shown below:
Author SONG, Yunlong
WANG, Guocheng
TENG, Guosheng
LIU, Peng
JIN, Lei
LIN, Daizong
YAN, Hongbo
SHEN, Guangyuan
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– fullname: YAN, Hongbo
– fullname: LIU, Peng
– fullname: LIN, Daizong
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Snippet A compound of Formula I, or a racemate, a racemate, a stereoisomer, a tautomer, an isotopically labeled compound, an N-oxide, a solvate, a polymorph, a...
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SubjectTerms CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Title SPIROINDOLINE DERIVATIVE, AND PREPARATION METHOD AND MEDICAL USE THEREOF
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