OLIGONUCLEOTIDE COMPOSITIONS AND METHODS OF USE THEREOF

• Main Authors: Butler, David Charles Donnell, Lu, Genliang, Iwamoto, Naoki, Zhang, Jason Jingxin, Wisniewska, Hanna Maria, Cheng, Xiayun, Vargeese, Chandra, Cho, Young Jin, Marappan, Subramanian, Apponi, Luciano Henrique, Vathipadiekal, Vinod
• Format: Patent
• Language: English
• Published: 30.05.2024
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; VINEGAR; WINE

Among other things, the present disclosure provides designed PNPLA3 oligonucleotides, compositions, and methods thereof. In some embodiments, provided oligonucleotide compositions provide improved single-stranded RNA interference and/or RNase H-mediated knockdown. Among other things, the present dis...