4-AMINOQUINAZOLINE COMPOUND

[Problem] A compound useful as an active ingredient of a pharmaceutical composition for treating pancreatic cancer is provided.[Solution] The present inventors have studied about a compound that is useful as an active ingredient of a pharmaceutical composition for treating pancreatic cancer and have...

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Main Authors MORIKAWA, Takahiro, KURAMOTO, Kazuyuki, IMADA, Sunao, HAMAGUCHI, Hisao, KURIWAKI, Ikumi, SATO, Ryo, ISHIOKA, Hiroki, FUKUDOME, Hiroki, KAWAGUCHI, Kenichi, IMAIZUMI, Tomoyoshi, KAWAMINAMI, Eiji, SEKI, Yohei, OKUMURA, Mitsuaki, NAGASHIMA, Takeyuki
Format Patent
LanguageEnglish
Published 09.05.2024
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Abstract [Problem] A compound useful as an active ingredient of a pharmaceutical composition for treating pancreatic cancer is provided.[Solution] The present inventors have studied about a compound that is useful as an active ingredient of a pharmaceutical composition for treating pancreatic cancer and have found that a 4-aminoquinazoline compound has an excellent G12D mutant KRAS inhibition activity and can be used as a therapeutic agent for pancreatic cancer, thus completing the present invention. The 4-aminoquinazoline compound of the present invention or a salt thereof can be used as a therapeutic agent for pancreatic cancer.
AbstractList [Problem] A compound useful as an active ingredient of a pharmaceutical composition for treating pancreatic cancer is provided.[Solution] The present inventors have studied about a compound that is useful as an active ingredient of a pharmaceutical composition for treating pancreatic cancer and have found that a 4-aminoquinazoline compound has an excellent G12D mutant KRAS inhibition activity and can be used as a therapeutic agent for pancreatic cancer, thus completing the present invention. The 4-aminoquinazoline compound of the present invention or a salt thereof can be used as a therapeutic agent for pancreatic cancer.
Author IMAIZUMI, Tomoyoshi
ISHIOKA, Hiroki
KURIWAKI, Ikumi
KAWAGUCHI, Kenichi
SEKI, Yohei
IMADA, Sunao
OKUMURA, Mitsuaki
HAMAGUCHI, Hisao
KAWAMINAMI, Eiji
FUKUDOME, Hiroki
NAGASHIMA, Takeyuki
SATO, Ryo
KURAMOTO, Kazuyuki
MORIKAWA, Takahiro
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– fullname: HAMAGUCHI, Hisao
– fullname: KURIWAKI, Ikumi
– fullname: SATO, Ryo
– fullname: ISHIOKA, Hiroki
– fullname: FUKUDOME, Hiroki
– fullname: KAWAGUCHI, Kenichi
– fullname: IMAIZUMI, Tomoyoshi
– fullname: KAWAMINAMI, Eiji
– fullname: SEKI, Yohei
– fullname: OKUMURA, Mitsuaki
– fullname: NAGASHIMA, Takeyuki
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Snippet [Problem] A compound useful as an active ingredient of a pharmaceutical composition for treating pancreatic cancer is provided.[Solution] The present inventors...
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SubjectTerms CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Title 4-AMINOQUINAZOLINE COMPOUND
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