PURINONE COMPOUNDS AND THEIR USE IN TREATING CANCER
The specification generally relates to compounds of Formula (I):and pharmaceutically acceptable salts thereof, where R1, A1, A2 and A3 have any of the meanings defined herein. The specification also relates to the use of such compounds and salts thereof to treat or prevent DNA-PK mediated disease, i...
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| Main Authors | , , , |
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| Format | Patent |
| Language | English |
| Published |
09.05.2024
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| Subjects | |
| Online Access | Get full text |
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| Abstract | The specification generally relates to compounds of Formula (I):and pharmaceutically acceptable salts thereof, where R1, A1, A2 and A3 have any of the meanings defined herein. The specification also relates to the use of such compounds and salts thereof to treat or prevent DNA-PK mediated disease, including cancer. The specification further relates to pharmaceutical compositions comprising such compounds and salts; kits comprising such compounds and salts; methods of manufacture of such compounds and salts; intermediates useful in the manufacture of such compounds and salts; and to methods of treating DNA-PK mediated disease, including cancer, using such compounds and salts. |
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| AbstractList | The specification generally relates to compounds of Formula (I):and pharmaceutically acceptable salts thereof, where R1, A1, A2 and A3 have any of the meanings defined herein. The specification also relates to the use of such compounds and salts thereof to treat or prevent DNA-PK mediated disease, including cancer. The specification further relates to pharmaceutical compositions comprising such compounds and salts; kits comprising such compounds and salts; methods of manufacture of such compounds and salts; intermediates useful in the manufacture of such compounds and salts; and to methods of treating DNA-PK mediated disease, including cancer, using such compounds and salts. |
| Author | HOWARD, Martin Richard GOLDBERG, Frederick Woolf TING, Attilla Kuan Tsuei FINLAY, Maurice Raymond Verschoyle |
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| RelatedCompanies | CANCER RESEARCH TECHNOLOGY LIMITED ASTRAZENECA AB |
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| Snippet | The specification generally relates to compounds of Formula (I):and pharmaceutically acceptable salts thereof, where R1, A1, A2 and A3 have any of the meanings... |
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| SubjectTerms | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| Title | PURINONE COMPOUNDS AND THEIR USE IN TREATING CANCER |
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