ANTI-IL-36 ANTIBODIES AND METHODS OF USE THEREOF

• Main Authors: Lee, Chingwei Vivian, Patel, Ashka Bharat, Scharf, Louise, Bharill, Shashank, Fuh-Kelly, Germaine, Thai, Tina, Karrer, Erik Edward
• Format: Patent
• Language: English
• Published: 25.04.2024
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present disclosure provides binding proteins, such as antibodies and antigen-binding fragments, which specifically bind to human IL-36 cytokines, IL-36α, IL-36β, and/or IL-36γ, and block the IL-36 stimulated signaling pathways. Compositions comprising such binding proteins and methods of making...