BRYOSTATIN COMPOUNDS AND METHODS OF PREPARING THE SAME

• Main Authors: Ho, Stephen, Shimizu, Akira, Sloane, Jack, Wender, Paul, Quiroz, Ryan, Stevens, Matthew C, Hardman, Clayton, Ryckbosch, Steven, Jeffreys, Matthew S
• Format: Patent
• Language: English
• Published: 11.04.2024
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Methods for preparing a variety of bryostatin compounds are provided. The subject methods provide for preparation of bryostatin 1 in multi-gram quantities in a low and unprecedented number of convergent synthetic steps from commercially available materials. The subject methods are scalable with low...