BIODEGRADABLE LUNG SEALANTS
The invention relates to a rapid setting liquid lung sealant that forms a highly adherent and elastic hydrogel. Provided are lung sealants comprising two high molecular weight (20 kDa) multi-arm PEG compositions wherein the first PEG composition includes an alkaline buffer and the second PEG composi...
Saved in:
| Main Authors | , , |
|---|---|
| Format | Patent |
| Language | English |
| Published |
29.02.2024
|
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | The invention relates to a rapid setting liquid lung sealant that forms a highly adherent and elastic hydrogel. Provided are lung sealants comprising two high molecular weight (20 kDa) multi-arm PEG compositions wherein the first PEG composition includes an alkaline buffer and the second PEG composition includes a mildly acidic buffer for optimized set up time and extended working time. In some embodiments, the PEGs further comprise a radioprotectant such as tocopherol. In some embodiments, a colorant is added to one or both PEGs of the lung sealant to improve visualization of the lung sealant against human lung tissue. |
|---|---|
| AbstractList | The invention relates to a rapid setting liquid lung sealant that forms a highly adherent and elastic hydrogel. Provided are lung sealants comprising two high molecular weight (20 kDa) multi-arm PEG compositions wherein the first PEG composition includes an alkaline buffer and the second PEG composition includes a mildly acidic buffer for optimized set up time and extended working time. In some embodiments, the PEGs further comprise a radioprotectant such as tocopherol. In some embodiments, a colorant is added to one or both PEGs of the lung sealant to improve visualization of the lung sealant against human lung tissue. |
| Author | Dhanaraj, Sridevi Aitken, Brian Ghodbane, Salim A |
| Author_xml | – fullname: Dhanaraj, Sridevi – fullname: Aitken, Brian – fullname: Ghodbane, Salim A |
| BookMark | eNrjYmDJy89L5WSQdvL0d3F1D3J0cXTycVXwCfVzVwh2dfRx9AsJ5mFgTUvMKU7lhdLcDMpuriHOHrqpBfnxqcUFicmpeakl8aHBRgZGJgZmZgamRo6GxsSpAgChEiMQ |
| ContentType | Patent |
| DBID | EVB |
| DatabaseName | esp@cenet |
| DatabaseTitleList | |
| Database_xml | – sequence: 1 dbid: EVB name: esp@cenet url: http://worldwide.espacenet.com/singleLineSearch?locale=en_EP sourceTypes: Open Access Repository |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine Chemistry Sciences |
| ExternalDocumentID | US2024066052A1 |
| GroupedDBID | EVB |
| ID | FETCH-epo_espacenet_US2024066052A13 |
| IEDL.DBID | EVB |
| IngestDate | Fri Aug 23 06:56:25 EDT 2024 |
| IsOpenAccess | true |
| IsPeerReviewed | false |
| IsScholarly | false |
| Language | English |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-epo_espacenet_US2024066052A13 |
| Notes | Application Number: US202217898897 |
| OpenAccessLink | https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240229&DB=EPODOC&CC=US&NR=2024066052A1 |
| ParticipantIDs | epo_espacenet_US2024066052A1 |
| PublicationCentury | 2000 |
| PublicationDate | 20240229 |
| PublicationDateYYYYMMDD | 2024-02-29 |
| PublicationDate_xml | – month: 02 year: 2024 text: 20240229 day: 29 |
| PublicationDecade | 2020 |
| PublicationYear | 2024 |
| RelatedCompanies | Ethicon, Inc |
| RelatedCompanies_xml | – name: Ethicon, Inc |
| Score | 3.530993 |
| Snippet | The invention relates to a rapid setting liquid lung sealant that forms a highly adherent and elastic hydrogel. Provided are lung sealants comprising two high... |
| SourceID | epo |
| SourceType | Open Access Repository |
| SubjectTerms | HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| Title | BIODEGRADABLE LUNG SEALANTS |
| URI | https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240229&DB=EPODOC&locale=&CC=US&NR=2024066052A1 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwY2BQsUwxTElONjbVTTY0TNM1STRK0rVIM03TNTBIS04xMwJmTTPQbmRfPzOPUBOvCNMIJoYc2F4Y8Dmh5eDDEYE5KhmY30vA5XUBYhDLBby2slg_KRMolG_vFmLrogbtHYOmCoAdaBcnW9cAfxd_ZzVnZ9vQYDW_IIicGbDtbuQI7CuxghrSoJP2XcOcQPtSCpArFTdBBrYAoHl5JUIMTKl5wgyczrC714QZOHyhU95AJjT3FYswSDt5-ru4ugc5ujg6-bgq-IT6uSsEuzr6OPqFBIsyKLu5hjh76AJtiYd7Kj40GNlJxmIMLMDufqoEg4JFqkVKoolxSrKBRapJYpJJkplRYpIFsCOZaJZknGRqIskgg88kKfzS0gxcIC54U7alDANLSVFpqiywWi1JkgOHBgACMHex |
| link.rule.ids | 230,309,786,891,25594,76903 |
| linkProvider | European Patent Office |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1LS8NAEB5KFetNq2Jt1YCSWzBv00OQPJtqHqVJpLeSzQMEqcVG_PtO1lR76m3ZgdkHfDv77e43C3A_LoQizyWFywWh4uRMJJxWKRXH81VeqCJCU23UyEGoeqn8vFAWHXjfamFontBvmhwREZUj3mu6Xq__D7Fs-rZy80DesOrjyU10m23ZcXNVgATaNnVnFtmRxVqWnsZsOP-1qbh3Fw3kSgePSAopWXo1G13KejeouCdwOEN_q_oUOuWqDz1r-_daH46C9sobiy36NmcwNKeR7Uzmhm2YvsP4aThhYsfwjTCJz-HOdRLL47CV5d-glmm82yXpArpI98tLYLRSKzJZKnJeK-WMyEQVM6IhkcxUIhFFHsBon6er_eZb6HlJ4C_9afgyhOPGRAXa4xF068-v8hpDbE1u6Mz8AL9neps |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Apatent&rft.title=BIODEGRADABLE+LUNG+SEALANTS&rft.inventor=Dhanaraj%2C+Sridevi&rft.inventor=Aitken%2C+Brian&rft.inventor=Ghodbane%2C+Salim+A&rft.date=2024-02-29&rft.externalDBID=A1&rft.externalDocID=US2024066052A1 |