MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR

This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) having core structure (I), pharmaceutical compositions containing at least one such modulator, methods of treatment of CFTR mediated diseases, including cystic fibrosis, using such modulators and pharma...

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Main Authors ZHOU, Jinglan, HADIDA RUAH, Sara Sabina, MCCARTNEY, Jason, MILLER, Mark Thomas, ARUMUGAM, Vijayalaksmi, CLEVELAND, Thomas, TRAN, Joe A, DWIGHT, Timothy A, GROOTENHUIS, Peter, FANNING, Lev Tyler Dewey, DINH, Andrew, FRIEMAN, Bryan A, ABRAHAM, Sunny, SILINA, Alina, KRENITSKY, Paul, PIERRE, Fabrice, ANDERSON, Corey Don, COON, Timothy Richard, VALDEZ, Lino, CLEMENS, Jeremy, ISHIHARA, Yoshihiro, ABELA, Alexander Russell, CHAU, Jaclyn
Format Patent
LanguageEnglish
Published 18.01.2024
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) having core structure (I), pharmaceutical compositions containing at least one such modulator, methods of treatment of CFTR mediated diseases, including cystic fibrosis, using such modulators and pharmaceutical compositions, combination pharmaceutical compositions and combination therapies, and processes and intermediates for making such modulators.
Bibliography:Application Number: US202118030530