OPTIMIZED ANTIBODIES THAT TARGET CD19

• Main Authors: Pong, Erik Weiking, Bernett, Matthew J, Richards, John O, Zhukovsky, Eugene Alexander, Lazar, Gregory Alan, Karki, Sher Bahadur, Desjarlais, John R, Chu, Seung Yup
• Format: Patent
• Language: English
• Published: 26.10.2023
• Subjects: CHEMISTRY; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES

The present invention describes antibodies that target CD19, wherein the antibodies comprise at least one modification relative to a parent antibody, wherein the modification alters affinity to an FcγR or alters effector function as compared to the parent antibody. Also disclosed are methods of usin...