MOLECULAR SIGNATURE OF A COMMON ALOPECIC STATE, ASSOCIATED WITH CELL JUNCTIONS

• Main Authors: MAHE, Yann, BAKKAR, Khalid, BOU SAMRA, Elias
• Format: Patent
• Language: English
• Published: 24.08.2023
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; ENZYMOLOGY; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; PROCESSES OF PREPARING SUCH COMPOSITIONS; SPIRITS; VINEGAR; WINE

The present invention relates to a method for the in vitro prognosis and/or diagnosis of a common alopecic state of the scalp in a subject, comprising at least one step a) of measuring the expression level, in a biological sample from an area suspected of being an alopecic area or of becoming an alopecic area in said subject, of at least one gene involved in the intercellular junctions of the scalp and/or of the hair follicle chosen from CDH1, ACTB, ACTBL2, TUBB, TUBB2A, GSN, MYO3B, MYO5B, MYO6, DSG2, DSG3, DSG4, DSC2, GJB2, GJA1, GJB6, GJA3, TJP2, CLDN8, CLDN10, CLDN19, and optionally of at least one gene chosen from CTNNB1 and CTNND2, wherein said common alopecic state is chosen from androgenetic alopecia, traction alopecia, female pattern hair loss, cicatricial alopecia, telogen effluvium, stress-related alopecia, seasonal alopecia, age-related alopecia and micro-inflammatory alopecia.The invention also relates to an in vitro method for evaluating the efficacy of a treatment of a common alopecic state, to a cosmetic treatment method, to the use of a modulator of said abovementioned gene(s), and also to a method for identifying a compound which allows the prevention and/or treatment of a common alopecic state.