ANTIFUNGAL PRODRUGS

• Main Authors: PAGNIEZ, FABRICE, LE PAPE, PATRICE, TESSIER, ARNAUD, LEBRETON, JACQUES, GRATIEN, GILLES-OLIVIER
• Format: Patent
• Language: English
• Published: 13.07.2023
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention relates to an antifungal prodrug which comprises an antifungal moiety which is linked to a trigger moiety by means of a self-immolative spacer. The trigger moiety is selected from glycosyl residues and oligosaccharides, stabilizes the self-immolative spacer and is cleavable by a pathog...