DAPHNANE DITERPENOID RESISTANT TO PROSTATE CANCER AND PREPARATION METHOD THEREOF
The invention relates to a daphnane diterpenoid resistant to a prostate cancer and a preparation method thereof. A daphnane diterpenoid compound as represented by formula (I) or formula (II) significantly inhibits the proliferation of various prostate cancer cells; the activities of some such compou...
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| Main Authors | , , , , |
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| Format | Patent |
| Language | English |
| Published |
25.05.2023
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| Subjects | |
| Online Access | Get full text |
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| Abstract | The invention relates to a daphnane diterpenoid resistant to a prostate cancer and a preparation method thereof. A daphnane diterpenoid compound as represented by formula (I) or formula (II) significantly inhibits the proliferation of various prostate cancer cells; the activities of some such compounds at a cellular level and an animal level are higher than that of the existing clinical targeting drug enzalutamide; and the daphnane diterpenoid compounds have strong synergistic effects when used in combination with the enzalutamide and are expected to become candidate drugs for treatment or adjuvant treatment of a castration-resistant prostate cancer. |
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| AbstractList | The invention relates to a daphnane diterpenoid resistant to a prostate cancer and a preparation method thereof. A daphnane diterpenoid compound as represented by formula (I) or formula (II) significantly inhibits the proliferation of various prostate cancer cells; the activities of some such compounds at a cellular level and an animal level are higher than that of the existing clinical targeting drug enzalutamide; and the daphnane diterpenoid compounds have strong synergistic effects when used in combination with the enzalutamide and are expected to become candidate drugs for treatment or adjuvant treatment of a castration-resistant prostate cancer. |
| Author | YIN, Sheng Yan, Xuelong Huang, Jialuo Wang, Junjian Tang, Guihua |
| Author_xml | – fullname: Tang, Guihua – fullname: YIN, Sheng – fullname: Wang, Junjian – fullname: Yan, Xuelong – fullname: Huang, Jialuo |
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| Notes | Application Number: US202318157529 |
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| Snippet | The invention relates to a daphnane diterpenoid resistant to a prostate cancer and a preparation method thereof. A daphnane diterpenoid compound as represented... |
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| Title | DAPHNANE DITERPENOID RESISTANT TO PROSTATE CANCER AND PREPARATION METHOD THEREOF |
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