PROCESS FOR PREPARING PURIFIED DRUG CONJUGATES

The invention provides a process for preparing a cell-binding agent chemically coupled to a drug. The process comprises covalently attaching a linker to a cell-binding agent, a purification step, conjugating a drug to the cell-binding agent and a subsequent purification step.

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Bibliographic Details
Main Authors AMPHLETT, Godfrey W, JIN, Shengjin, MESHULAM, Deborah H, WANG, Yong, DAI, Yong
Format Patent
LanguageEnglish
Published 25.05.2023
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The invention provides a process for preparing a cell-binding agent chemically coupled to a drug. The process comprises covalently attaching a linker to a cell-binding agent, a purification step, conjugating a drug to the cell-binding agent and a subsequent purification step.
Bibliography:Application Number: US202217940297