INHIBITORS OF GLUCOCORTICOID RECEPTOR

The present invention relates generally to compositions and methods for treating cancer and hypercortisolism. Provided herein are substituted steroidal derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition of...

Full description

Saved in:
Bibliographic Details
Main Authors EKSTEROWICZ, John, ZHOU, Haiying, REW, Yosup, ZHU, Liusheng, FANTIN, Valeria R, YAN, Xuelei, SUN, Daqing, MEDINA, Julio C, BALBAS, Minna Delarae, DU, Xiaohui, McGEE, Lawrence R
Format Patent
LanguageEnglish
Published 30.03.2023
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
STEROIDS
Online AccessGet full text

Cover

Abstract The present invention relates generally to compositions and methods for treating cancer and hypercortisolism. Provided herein are substituted steroidal derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition of glucocorticoid receptors. Furthermore, the subject compounds and compositions are useful for the treatment of cancer.
AbstractList The present invention relates generally to compositions and methods for treating cancer and hypercortisolism. Provided herein are substituted steroidal derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition of glucocorticoid receptors. Furthermore, the subject compounds and compositions are useful for the treatment of cancer.
Author YAN, Xuelei
REW, Yosup
MEDINA, Julio C
FANTIN, Valeria R
McGEE, Lawrence R
ZHU, Liusheng
BALBAS, Minna Delarae
SUN, Daqing
ZHOU, Haiying
DU, Xiaohui
EKSTEROWICZ, John
Author_xml – fullname: EKSTEROWICZ, John
– fullname: ZHOU, Haiying
– fullname: REW, Yosup
– fullname: ZHU, Liusheng
– fullname: FANTIN, Valeria R
– fullname: YAN, Xuelei
– fullname: SUN, Daqing
– fullname: MEDINA, Julio C
– fullname: BALBAS, Minna Delarae
– fullname: DU, Xiaohui
– fullname: McGEE, Lawrence R
BookMark eNrjYmDJy89L5WRQ9fTz8HTyDPEPClbwd1Nw9wl19nf2DwrxdPb3dFEIcnV2DQDK8TCwpiXmFKfyQmluBmU31xBnD93Ugvz41OKCxOTUvNSS-NBgIwMjYwNLMwtzA0dDY-JUAQAwpiY2
ContentType Patent
DBID EVB
DatabaseName esp@cenet
DatabaseTitleList
Database_xml – sequence: 1
  dbid: EVB
  name: esp@cenet
  url: http://worldwide.espacenet.com/singleLineSearch?locale=en_EP
  sourceTypes: Open Access Repository
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
Chemistry
Sciences
ExternalDocumentID US2023096870A1
GroupedDBID EVB
ID FETCH-epo_espacenet_US2023096870A13
IEDL.DBID EVB
IngestDate Fri Jul 19 12:58:05 EDT 2024
IsOpenAccess true
IsPeerReviewed false
IsScholarly false
Language English
LinkModel DirectLink
MergedId FETCHMERGED-epo_espacenet_US2023096870A13
Notes Application Number: US202217887777
OpenAccessLink https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230330&DB=EPODOC&CC=US&NR=2023096870A1
ParticipantIDs epo_espacenet_US2023096870A1
PublicationCentury 2000
PublicationDate 20230330
PublicationDateYYYYMMDD 2023-03-30
PublicationDate_xml – month: 03
  year: 2023
  text: 20230330
  day: 30
PublicationDecade 2020
PublicationYear 2023
RelatedCompanies ORIC Pharmaceuticals, Inc
RelatedCompanies_xml – name: ORIC Pharmaceuticals, Inc
Score 3.4541748
Snippet The present invention relates generally to compositions and methods for treating cancer and hypercortisolism. Provided herein are substituted steroidal...
SourceID epo
SourceType Open Access Repository
SubjectTerms CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
STEROIDS
Title INHIBITORS OF GLUCOCORTICOID RECEPTOR
URI https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230330&DB=EPODOC&locale=&CC=US&NR=2023096870A1
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3dT4MwEL8s06hvOjVOpyFReSPi6Nh4IEYKCMZRwofZ20KhJCZmLg7jv--BTPe0t7aXXD_S693v2rsC3Bi5wbk2KZVyKBCgZKpQeKYVChdGSTJteM957YecBrqXkufZaNaB93UsTJMn9LtJjogSlaO8V815vfx3YtnN28rVHX_Dpo8HNzFtuUXHaE8jPpdty3RCZjMqU2qmsRxEvzRDx935iFhppzak60z7zqtVx6UsN5WKewi7IfJbVEfQEYse7NP132s92Ju2V95YbKVvdQy3fuD5lp-wKJaYKz29pJRRFiU-Zb4tRQ51QqSdwLXrJNRTsL_53_Tmabw5OO0Uugj8xRlIZamPSrQ_VJ6PSaEToxAZmRgZ18h4yIu8D4NtnM63ky_goK428XXqALrV55e4RAVb8atmXX4A_wt7cg
link.rule.ids 230,309,786,891,25594,76906
linkProvider European Patent Office
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3fT4MwEL4s0zjfdGqcTiVReSPOwWA8ECMFBAW6MDB7WyiUxMTMxWH89z2Q6Z721vRLrj_S693X9q4AN3qmMyaPC6kYciQo6YBLLJVziXG9UFJ5eM9YdQ4ZhKqbKM-z0awF7-tYmDpP6HedHBE1KkN9L-v9evl_iGXVbytXd-wNqz4enNiwxIYdoz-N_Fy0TMOeUIsSkRAjmYph9IvpKq7OR-RKO1qVn7dynl7NKi5luWlUnAPYnaC8RXkILb7oQoes_17rwl7QXHljsdG-1RHceqHrmV5Mo6lAHeHJTwglNIo9Qj1LiGxiTxA7hmvHjokrYXvzv-HNk-lm5-QTaCPx56cgFIU6KtD_GLBMU3JV0XOeKmM9ZbKiDVme9aC_TdLZdvgKOm4c-HPfC1_OYb-C6li7QR_a5ecXv0BjW7LLeo5-AO0-fl8
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Apatent&rft.title=INHIBITORS+OF+GLUCOCORTICOID+RECEPTOR&rft.inventor=EKSTEROWICZ%2C+John&rft.inventor=ZHOU%2C+Haiying&rft.inventor=REW%2C+Yosup&rft.inventor=ZHU%2C+Liusheng&rft.inventor=FANTIN%2C+Valeria+R&rft.inventor=YAN%2C+Xuelei&rft.inventor=SUN%2C+Daqing&rft.inventor=MEDINA%2C+Julio+C&rft.inventor=BALBAS%2C+Minna+Delarae&rft.inventor=DU%2C+Xiaohui&rft.inventor=McGEE%2C+Lawrence+R&rft.date=2023-03-30&rft.externalDBID=A1&rft.externalDocID=US2023096870A1