SENSING OF MOLECULES BY ELECTROCHEMICAL DETECTION OF NANOPARTICLES
The invention relates to a method for sensing target molecules in an analyte solution, a sensor for sensing target molecules in an analyte solution and a measurement system for sensing target molecules in an analyte solution. The method comprises providing a capture surface, wherein a plurality of c...
Saved in:
Main Authors | , , , , , , , |
---|---|
Format | Patent |
Language | English |
Published |
09.02.2023
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | The invention relates to a method for sensing target molecules in an analyte solution, a sensor for sensing target molecules in an analyte solution and a measurement system for sensing target molecules in an analyte solution. The method comprises providing a capture surface, wherein a plurality of capture molecules are arranged on the capture surface, each of the capture molecules being configured to bind to at least one of said target molecules. The method further comprises exposing the capture surface to the analyte solution to allow target molecules to bind to the capture molecules arranged on the capture surface. The capture surface is then exposed to a solution containing detection molecules, wherein each of the detection molecules contains an electrochemically active nanoparticle and is configured to bind to one of said target molecules bound to a capture molecule, thereby allowing said electrochemically active nanoparticles to bind to the capture surface through formation of a bond between the respective detection molecule comprising said nanoparticle and one of said target molecules bound to one of said capture molecules arranged on the capture surface. The method further comprises releasing nanoparticles that are bound to the capture surface and, after releasing said nanoparticles from the capture surface, determining an electrical signal at a detection electrode caused by electrochemical reactions of said nanoparticles released from the capture surface. |
---|---|
AbstractList | The invention relates to a method for sensing target molecules in an analyte solution, a sensor for sensing target molecules in an analyte solution and a measurement system for sensing target molecules in an analyte solution. The method comprises providing a capture surface, wherein a plurality of capture molecules are arranged on the capture surface, each of the capture molecules being configured to bind to at least one of said target molecules. The method further comprises exposing the capture surface to the analyte solution to allow target molecules to bind to the capture molecules arranged on the capture surface. The capture surface is then exposed to a solution containing detection molecules, wherein each of the detection molecules contains an electrochemically active nanoparticle and is configured to bind to one of said target molecules bound to a capture molecule, thereby allowing said electrochemically active nanoparticles to bind to the capture surface through formation of a bond between the respective detection molecule comprising said nanoparticle and one of said target molecules bound to one of said capture molecules arranged on the capture surface. The method further comprises releasing nanoparticles that are bound to the capture surface and, after releasing said nanoparticles from the capture surface, determining an electrical signal at a detection electrode caused by electrochemical reactions of said nanoparticles released from the capture surface. |
Author | WEISS, Lennart HAYDEN, Oliver ADLY HASSAN, Nouran Yehia THIERRY, Benjamin GROB, Leroy TRAN, Phu Duy WOLFRUM, Bernhard RINKLIN, Philipp |
Author_xml | – fullname: THIERRY, Benjamin – fullname: TRAN, Phu Duy – fullname: ADLY HASSAN, Nouran Yehia – fullname: GROB, Leroy – fullname: WOLFRUM, Bernhard – fullname: WEISS, Lennart – fullname: RINKLIN, Philipp – fullname: HAYDEN, Oliver |
BookMark | eNrjYmDJy89L5WRwCnb1C_b0c1fwd1Pw9fdxdQ71cQ1WcIpUcAWyQ4L8nT1cfT2dHX0UXFxDgAKe_n4glX6Ofv4BjkEhns5A1TwMrGmJOcWpvFCam0HZzTXE2UM3tSA_PrW4IDE5NS-1JD402MjAyNjAxNDQ2MzR0Jg4VQDPwi3i |
ContentType | Patent |
DBID | EVB |
DatabaseName | esp@cenet |
DatabaseTitleList | |
Database_xml | – sequence: 1 dbid: EVB name: esp@cenet url: http://worldwide.espacenet.com/singleLineSearch?locale=en_EP sourceTypes: Open Access Repository |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Medicine Chemistry Sciences Physics |
ExternalDocumentID | US2023041136A1 |
GroupedDBID | EVB |
ID | FETCH-epo_espacenet_US2023041136A13 |
IEDL.DBID | EVB |
IngestDate | Fri Jul 19 14:45:43 EDT 2024 |
IsOpenAccess | true |
IsPeerReviewed | false |
IsScholarly | false |
Language | English |
LinkModel | DirectLink |
MergedId | FETCHMERGED-epo_espacenet_US2023041136A13 |
Notes | Application Number: US202117792185 |
OpenAccessLink | https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230209&DB=EPODOC&CC=US&NR=2023041136A1 |
ParticipantIDs | epo_espacenet_US2023041136A1 |
PublicationCentury | 2000 |
PublicationDate | 20230209 |
PublicationDateYYYYMMDD | 2023-02-09 |
PublicationDate_xml | – month: 02 year: 2023 text: 20230209 day: 09 |
PublicationDecade | 2020 |
PublicationYear | 2023 |
RelatedCompanies | TECHNISCHE UNIVERSITÄT MÜNCHEN |
RelatedCompanies_xml | – name: TECHNISCHE UNIVERSITÄT MÜNCHEN |
Score | 3.4562352 |
Snippet | The invention relates to a method for sensing target molecules in an analyte solution, a sensor for sensing target molecules in an analyte solution and a... |
SourceID | epo |
SourceType | Open Access Repository |
SubjectTerms | INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING PHYSICS TESTING |
Title | SENSING OF MOLECULES BY ELECTROCHEMICAL DETECTION OF NANOPARTICLES |
URI | https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230209&DB=EPODOC&locale=&CC=US&NR=2023041136A1 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3dS8MwED_G_HzTqvgxpaD0rTi31G0PQ9Y0dZP1g7WV-TTaLAVBuuEq_vte4qp72luSO44kcLnfJXcXgDuSScMshMlFZpmkQ5pm17LmZg-tueh2BJ-nMhvZ8x-HCXmZWtMafFS5MKpO6LcqjogaxVHfS3VeL_8vsRwVW7m6z95xaPHkxn3HWHvHiKdbzZ7h2H0WBk5ADUr7SWT4k18akR-YDNBX2pFAWlbaZ6-2zEtZbhoV9wh2Q5RXlMdQE4UGB7T6e02DfW_95K3BnorR5CscXOvh6gTsiPnRyH_WA1f3gjGjyZhFuv2mM2zHk6AqdKA7LGYqTERy-gM_CBHAjihyn8Kty2I6NHFas79dmCXR5hraZ1AvFoU4Bz3jCKHy7CFHT4S0cyttpRxBj2hx9Hxzkl9AY5uky-3kKziUXRWo3GtAvfz8Etdoh8vsRm3fD3hChSo |
link.rule.ids | 230,309,786,891,25594,76903 |
linkProvider | European Patent Office |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3dT8IwEL8Q_MA3RY0fqEs0e1tE6AQeiGFdJ-jWEbYZeFpY6RITM4jM-O97q6A88dbcNZf2kuvdr727AtyRpHDMUhpCJqZBWqRutE1zZnTQm8t2S4rZtKhG9vhjPyIvY3Ncgo91LYzqE_qtmiOiRQm091yd14v_Syxb5VYu75N3JM2fnLBr6yt0jPF0o97RbavLhr7tU53SbhTofPTLI8UHJj3ESjstBIUKLL1ZRV3KYtOpOIewO0R5WX4EJZlVoULXf69VYd9bPXlXYU_laIolEld2uDwGK2A8GPBnzXc0z3cZjVwWaNZEYzgOR_660YFms5CpNJFiJu9xf4gB7IDi7BO4dVhI-wYuK_7TQhwFm3tonkI5m2fyDLREYAiVJg8pIhHSTM1pYyow6JENgZtMSXoOtW2SLrazb6DSDz03dgf89RIOCpZKWu7UoJx_fskr9Ml5cq1U-QPXWIgU |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Apatent&rft.title=SENSING+OF+MOLECULES+BY+ELECTROCHEMICAL+DETECTION+OF+NANOPARTICLES&rft.inventor=THIERRY%2C+Benjamin&rft.inventor=TRAN%2C+Phu+Duy&rft.inventor=ADLY+HASSAN%2C+Nouran+Yehia&rft.inventor=GROB%2C+Leroy&rft.inventor=WOLFRUM%2C+Bernhard&rft.inventor=WEISS%2C+Lennart&rft.inventor=RINKLIN%2C+Philipp&rft.inventor=HAYDEN%2C+Oliver&rft.date=2023-02-09&rft.externalDBID=A1&rft.externalDocID=US2023041136A1 |