BICYCLIC HETEROARYL COMPOUNDS USEFUL AS IRAK4 INHIBITORS
Disclosed are compounds of Formula (I) or a salt or prodrug thereof, wherein: X is C or N; Y is C or N; Z is CR4 or N; provided that when: (i) X is N, then Y is C; and (ii) X is C, then Y is N and Z is N; and wherein R1, R2, R3, and R4 are define herein. Also disclosed are methods of using such comp...
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Main Authors | , , , , , |
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Format | Patent |
Language | English |
Published |
01.12.2022
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Subjects | |
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Abstract | Disclosed are compounds of Formula (I) or a salt or prodrug thereof, wherein: X is C or N; Y is C or N; Z is CR4 or N; provided that when: (i) X is N, then Y is C; and (ii) X is C, then Y is N and Z is N; and wherein R1, R2, R3, and R4 are define herein. Also disclosed are methods of using such compounds as modulators of IRAK4, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing inflammatory and autoimmune diseases, or in the treatment of cancer. |
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AbstractList | Disclosed are compounds of Formula (I) or a salt or prodrug thereof, wherein: X is C or N; Y is C or N; Z is CR4 or N; provided that when: (i) X is N, then Y is C; and (ii) X is C, then Y is N and Z is N; and wherein R1, R2, R3, and R4 are define herein. Also disclosed are methods of using such compounds as modulators of IRAK4, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing inflammatory and autoimmune diseases, or in the treatment of cancer. |
Author | Paidi, Venkatram Reddy Hynes, John Polimera, Subba Rao Nair, Satheesh Kesavan Santella, Joseph B Wu, Hong |
Author_xml | – fullname: Nair, Satheesh Kesavan – fullname: Santella, Joseph B – fullname: Hynes, John – fullname: Wu, Hong – fullname: Polimera, Subba Rao – fullname: Paidi, Venkatram Reddy |
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Snippet | Disclosed are compounds of Formula (I) or a salt or prodrug thereof, wherein: X is C or N; Y is C or N; Z is CR4 or N; provided that when: (i) X is N, then Y... |
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SubjectTerms | CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY |
Title | BICYCLIC HETEROARYL COMPOUNDS USEFUL AS IRAK4 INHIBITORS |
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