IMPROVED PURIFICATION PROCESSES FOR LIRAGLUTIDE

The present application relates to improved and effective purification processes and also relates to method of increasing the solubility of for GLP-1 analog and its derivatives particularly Liraglutide. The purification process of present application is advantageous not only in terms of providing th...

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Bibliographic Details
Main Authors GANDAVADI, Sunil Kumar, KROLL, Sebastian, RAMASWAMY, Karthik, SEKHAR, Nariyam Munaswamy, GAFFNEY, Philip, KOMARAVOLU, Yagna Kiran Kumar, MCCORMACK, Peter, BUDHDEV, Rajeev Rehani, ANNARAPU, Malleswara Reddy
Format Patent
LanguageEnglish
Published 24.11.2022
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The present application relates to improved and effective purification processes and also relates to method of increasing the solubility of for GLP-1 analog and its derivatives particularly Liraglutide. The purification process of present application is advantageous not only in terms of providing the highly pure peptide chemically but also in terms of affording peptide drug substance which is having good physical stability even at a large scale during holding or in-use period, while making drug substance compatible for formulation.
Bibliography:Application Number: US202017762246