PRODUCTION METHOD FOR BIFURCATED LIPID-LINKED OLIGONUCLEOTIDE, AND INTERMEDIATE
Provided are production methods capable of controlling quality of a bifurcated lipid-linked oligonucleotide, and intermediates which is useful for the production method, has good stability, and is easy to manage and analyze. Specifically, it is a method for producing a bifurcated lipid-linked oligon...
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Main Authors | , , , |
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Format | Patent |
Language | English |
Published |
25.08.2022
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Subjects | |
Online Access | Get full text |
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Summary: | Provided are production methods capable of controlling quality of a bifurcated lipid-linked oligonucleotide, and intermediates which is useful for the production method, has good stability, and is easy to manage and analyze. Specifically, it is a method for producing a bifurcated lipid-linked oligonucleotide including a step of reacting a compound of formula (II):wherein Pro1 to Pro4 are each independently a protecting group;Pro1 and Pro2 or Pro3 and Pro4 may be taken together to form a protecting group;m, n and p are each independently an integer of 0 to 5; andY is a group of a formula: -P(OC2H4CN)(N(i-Pr)2), or the like, with an oligonucleotide. |
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Bibliography: | Application Number: US202017616413 |