CHIMERIC ANTIGEN RECEPTOR EFFECTOR CELL SWITCHES WITH HUMANIZED TARGETING MOIETIES AND/OR OPTIMIZED CHIMERIC ANTIGEN RECEPTOR INTERACTING DOMAINS AND USES THEREOF

The present disclosure provides compositions, methods, kits, and platforms for selectively activating and deactivating chimeric receptor effector cells using humanized chimeric receptor effector cell switches that comprise a humanized targeting moiety that binds CD19 on a target cell and a chimeric...

Full description

Saved in:
Bibliographic Details
Main Authors VIAUD, Sophie, KHIALEEVA, Elvira, HAMPTON, Eric, SCHULTZ, Peter G, LABORDA, Eduardo, YOUNG, Travis S, RODGERS, David, WRIGHT, Timothy, PRESTA, Leonard
Format Patent
LanguageEnglish
Published 10.03.2022
Subjects
Online AccessGet full text

Cover

Loading…
Abstract The present disclosure provides compositions, methods, kits, and platforms for selectively activating and deactivating chimeric receptor effector cells using humanized chimeric receptor effector cell switches that comprise a humanized targeting moiety that binds CD19 on a target cell and a chimeric receptor interacting domain that binds to a chimeric receptor effector cell and/or chimeric receptor effector cell switches comprising optimized chimeric receptor interacting domains. Also disclosed are methods of treating disease and conditions with such chimeric receptor effector cells and chimeric receptor effector cell switches.
AbstractList The present disclosure provides compositions, methods, kits, and platforms for selectively activating and deactivating chimeric receptor effector cells using humanized chimeric receptor effector cell switches that comprise a humanized targeting moiety that binds CD19 on a target cell and a chimeric receptor interacting domain that binds to a chimeric receptor effector cell and/or chimeric receptor effector cell switches comprising optimized chimeric receptor interacting domains. Also disclosed are methods of treating disease and conditions with such chimeric receptor effector cells and chimeric receptor effector cell switches.
Author HAMPTON, Eric
SCHULTZ, Peter G
RODGERS, David
LABORDA, Eduardo
WRIGHT, Timothy
YOUNG, Travis S
KHIALEEVA, Elvira
PRESTA, Leonard
VIAUD, Sophie
Author_xml – fullname: VIAUD, Sophie
– fullname: KHIALEEVA, Elvira
– fullname: HAMPTON, Eric
– fullname: SCHULTZ, Peter G
– fullname: LABORDA, Eduardo
– fullname: YOUNG, Travis S
– fullname: RODGERS, David
– fullname: WRIGHT, Timothy
– fullname: PRESTA, Leonard
BookMark eNqNjr0KwjAUhTvo4N87XHAWa4sUx5DeNhdMUpIUwaUUiZO0hfpEPqmxuApO5wzfd-5dRrOu7_wienFBEg1xYMpRiQoMcqycNoBFgfxTOJ7PYC_kuEALIQWIWjJFV8zBMVOiI1WC1BRKIJjK90HTlSM5Mb9vkHJoGJ_8XEtGatKhtmHHCTSoi3U0v7eP0W--uYq2BYZfdn7oGz8O7c13_tnUNomTJM7S4yljh_Q_6g0P5kh5
ContentType Patent
DBID EVB
DatabaseName esp@cenet
DatabaseTitleList
Database_xml – sequence: 1
  dbid: EVB
  name: esp@cenet
  url: http://worldwide.espacenet.com/singleLineSearch?locale=en_EP
  sourceTypes: Open Access Repository
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
Chemistry
Sciences
ExternalDocumentID US2022073597A1
GroupedDBID EVB
ID FETCH-epo_espacenet_US2022073597A13
IEDL.DBID EVB
IngestDate Fri Oct 04 05:01:29 EDT 2024
IsOpenAccess true
IsPeerReviewed false
IsScholarly false
Language English
LinkModel DirectLink
MergedId FETCHMERGED-epo_espacenet_US2022073597A13
Notes Application Number: US202117461365
OpenAccessLink https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220310&DB=EPODOC&CC=US&NR=2022073597A1
ParticipantIDs epo_espacenet_US2022073597A1
PublicationCentury 2000
PublicationDate 20220310
PublicationDateYYYYMMDD 2022-03-10
PublicationDate_xml – month: 03
  year: 2022
  text: 20220310
  day: 10
PublicationDecade 2020
PublicationYear 2022
RelatedCompanies The Scripps Research Institute
RelatedCompanies_xml – name: The Scripps Research Institute
Score 3.3919556
Snippet The present disclosure provides compositions, methods, kits, and platforms for selectively activating and deactivating chimeric receptor effector cells using...
SourceID epo
SourceType Open Access Repository
SubjectTerms CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Title CHIMERIC ANTIGEN RECEPTOR EFFECTOR CELL SWITCHES WITH HUMANIZED TARGETING MOIETIES AND/OR OPTIMIZED CHIMERIC ANTIGEN RECEPTOR INTERACTING DOMAINS AND USES THEREOF
URI https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220310&DB=EPODOC&locale=&CC=US&NR=2022073597A1
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3dS8MwEA9jivqmU_FjSkDpW9lcu619GNKl6VpZP2hTHb6MtmYgSDdcxf_Hv9RL3HQv7imXJpfQhLvcL7lcELrVuJEZXDNVAA8dVTdmpppxI1d7maFnenE3a2diQ98Pem6qP0y6kxp6W9-FkXFCP2VwRJCoAuS9kvp68beJZUvfymUrf4VP83uHDWxlhY47HRHpUrGHAxqFdkgUQgZpogTxT1lfA_PZAqy0A4a0IRwA6eNQ3EtZbC4qziHajaC9sjpCNV420D5Zv73WQHv-6sgbyJX0LY_RF3E9-UgjtgLmjWiAY0poxMIYg7lJiSAIHY9x8uQx4tIEQ-piN_WtwHumNmZWPKLMC0bYDz0goIYV2C1gCyMGWkzU-b8PGT1XOJ0Avx36FuB-wY5TUMmYuTSmoXOCbhwKfavws9PfsZ2myebIaKeoXs5LfoZwW4e5Bcv7hReAGPOu2QPbbtYvuMnNfjfPzlFzW0sX24sv0YHIqtIxronq1fsHv4LVvcqv5aR8A2otnKw
link.rule.ids 230,309,786,891,25585,76894
linkProvider European Patent Office
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3dT4MwEG-WadQ3nRo_pjbR8EY2B9vgYTGslIHyFSi6-LIAdomJYYvD-P_4l3rFTffinnrp9drQ5q6_K9crQjcK11KNK7oMzkNHVrWpLqdcy-Reqqmpmt9O26k40Pf8np2o9-PuuIbeVndhqjyhn1VyRNCoHPS9rOz1_O8Qy6xiKxet7BWqZncWG5jS0jvudESmS8kcDmgYmAGRCBkkseRHP7y-AvDZAF9pC0C2LjLt08ehuJcyX99UrH20HUJ_RXmAarxooF2yenutgXa85S9vIJfatzhEX8R2qkcaseEzZ0R9HFFCQxZEGOAmJYIg1HVx_OQwYtMYQ2ljO_EM33mmJmZGNKLM8UfYCxwgoIXhmy0QC0IGVky0-X-MKnuuCDoBeTPwDPD7hThOwCRjZtOIBtYRurYojC3Dx05-53aSxOszoxyjejEr-AnCbRXWFpD3C8_BY8y6eg-w3bSfc53r_W6WnqLmpp7ONrOv0K7NPHfiOv7DOdoTLLkKkmuievn-wS9gpy-zy2qBvgHyup-f
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Apatent&rft.title=CHIMERIC+ANTIGEN+RECEPTOR+EFFECTOR+CELL+SWITCHES+WITH+HUMANIZED+TARGETING+MOIETIES+AND%2FOR+OPTIMIZED+CHIMERIC+ANTIGEN+RECEPTOR+INTERACTING+DOMAINS+AND+USES+THEREOF&rft.inventor=VIAUD%2C+Sophie&rft.inventor=KHIALEEVA%2C+Elvira&rft.inventor=HAMPTON%2C+Eric&rft.inventor=SCHULTZ%2C+Peter+G&rft.inventor=LABORDA%2C+Eduardo&rft.inventor=YOUNG%2C+Travis+S&rft.inventor=RODGERS%2C+David&rft.inventor=WRIGHT%2C+Timothy&rft.inventor=PRESTA%2C+Leonard&rft.date=2022-03-10&rft.externalDBID=A1&rft.externalDocID=US2022073597A1