METHOD FOR OBTAINING CRYSTALLINE 2'-FUCOSYLLACTOSE

• Main Authors: PUHL, Michael, OEDMAN, Peter, LETZEL, Anne-Catrin, SEIBERT-LUDWIG, Daniel, MALISZ, Jacek, VIERTELHAUS, Martin, SCHROEDER, Hartwing, WONG, Chung Huan, BARROS GROSS, Michael, WLOCH, Sebastian, KAPPERT, Emiel Jan
• Format: Patent
• Language: English
• Published: 16.12.2021
• Subjects: CHEMISTRY; DERIVATIVES THEREOF; METALLURGY; NUCLEIC ACIDS; NUCLEOSIDES; NUCLEOTIDES; ORGANIC CHEMISTRY; SUGARS

The present invention relates to a method for obtaining crystalline 2′-fucosyllactose from a 2′-FL raw material, which contains 2′-FL as a main constituent and at least 0.5% by weight, frequently at least 1% by weight, in particular at least 2% by weight, more particularly at least 5% by weight, and especially at least 8% by weight,based on the total amount of mono-and oligosaccharides in the raw material, of one or more mono- or oligosaccharides different from 2′-FL, where the method comprises a)providing a solution of the 2′-FL raw material in water, which does not contain more than 10% by weight, preferably not more than 7% by weight, more preferably not more than 5% by weight of organic solvents, based on the total amount of water; b) effecting the crystallization of 2′-FL from the solution provided in step a) by inducing conditions of a controlled super saturation in the solution; and c) separating crystalline 2′-FL from the mother liquor, and where during controlled supersaturation in step b) not more than 10% by weight, preferably not more than 7% by weight, more preferably not more than 5% by weight of organic solvents are present, based on the total amount of water present during step b).