AN RNA G-QUADRUPLEX STRUCTURE IN PRE-miRNA-1229 AS A THERAPEUTIC TARGET FOR ALZHEIMER'S DISEASE AND VARIOUS CANCERS

Provided is an agent that binds to a wild type or variant pre-miRNA-1229 comprising a G-quadruplex (GQ) structure, wherein binding of the agent to the wild type or variant pre-miRNA-1229 stabilizes the GQ structure of the wild type or variant pre-miRNA-1229. In some embodiments, the variant is rs229...

Full description

Saved in:
Bibliographic Details
Main Authors Mihailescu, Mihaela Rita, Imperatore, Joshua A
Format Patent
LanguageEnglish
Published 04.11.2021
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
Online AccessGet full text

Cover

Abstract Provided is an agent that binds to a wild type or variant pre-miRNA-1229 comprising a G-quadruplex (GQ) structure, wherein binding of the agent to the wild type or variant pre-miRNA-1229 stabilizes the GQ structure of the wild type or variant pre-miRNA-1229. In some embodiments, the variant is rs2291418. Provided is a method of treating a disease in a subject, comprising: administering a therapeutically effective amount of the agent to the subject. In some embodiments, the disease is Alzheimer's disease, cancer or coronary artery calcification.
AbstractList Provided is an agent that binds to a wild type or variant pre-miRNA-1229 comprising a G-quadruplex (GQ) structure, wherein binding of the agent to the wild type or variant pre-miRNA-1229 stabilizes the GQ structure of the wild type or variant pre-miRNA-1229. In some embodiments, the variant is rs2291418. Provided is a method of treating a disease in a subject, comprising: administering a therapeutically effective amount of the agent to the subject. In some embodiments, the disease is Alzheimer's disease, cancer or coronary artery calcification.
Author Mihailescu, Mihaela Rita
Imperatore, Joshua A
Author_xml – fullname: Mihailescu, Mihaela Rita
– fullname: Imperatore, Joshua A
BookMark eNqNyrsKwjAUANAOOvj6hwsOToE-FHG8pLdtoKb1JhFxKUUiCNoW6v-jgx_gdJYzDyZd3_lZMKIG1gi5ODlM2dUlXcBYdtI6JlAaaibxenyPiOL4AGgAwRbEWJOzSoJFzslCVjFgeS1IHYk3BlJlCA0B6hTOyKpyBiRqSWyWwfTePke_-rkI1hlZWQg_9I0fh_bmO_9unInDOEq24S7ZY5T8tz6PdDrU
ContentType Patent
DBID EVB
DatabaseName esp@cenet
DatabaseTitleList
Database_xml – sequence: 1
  dbid: EVB
  name: esp@cenet
  url: http://worldwide.espacenet.com/singleLineSearch?locale=en_EP
  sourceTypes: Open Access Repository
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
Chemistry
Sciences
ExternalDocumentID US2021340537A1
GroupedDBID EVB
ID FETCH-epo_espacenet_US2021340537A13
IEDL.DBID EVB
IngestDate Fri Jul 19 13:01:42 EDT 2024
IsOpenAccess true
IsPeerReviewed false
IsScholarly false
Language English
LinkModel DirectLink
MergedId FETCHMERGED-epo_espacenet_US2021340537A13
Notes Application Number: US202117301835
OpenAccessLink https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20211104&DB=EPODOC&CC=US&NR=2021340537A1
ParticipantIDs epo_espacenet_US2021340537A1
PublicationCentury 2000
PublicationDate 20211104
PublicationDateYYYYMMDD 2021-11-04
PublicationDate_xml – month: 11
  year: 2021
  text: 20211104
  day: 04
PublicationDecade 2020
PublicationYear 2021
RelatedCompanies DUQUESNE UNIVERSITY OF THE HOLY SPIRIT
RelatedCompanies_xml – name: DUQUESNE UNIVERSITY OF THE HOLY SPIRIT
Score 3.358141
Snippet Provided is an agent that binds to a wild type or variant pre-miRNA-1229 comprising a G-quadruplex (GQ) structure, wherein binding of the agent to the wild...
SourceID epo
SourceType Open Access Repository
SubjectTerms BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
Title AN RNA G-QUADRUPLEX STRUCTURE IN PRE-miRNA-1229 AS A THERAPEUTIC TARGET FOR ALZHEIMER'S DISEASE AND VARIOUS CANCERS
URI https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20211104&DB=EPODOC&locale=&CC=US&NR=2021340537A1
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3dT8IwEG-IGvVNUeMHmks0-LQIbHzsgZjSFTYDY2k3QnwhlI2ERAeRGf99rwsoT7z1ek3TXnLX_tr7IORp3oqTecOODVVp2oY1U6hziaWQbKhWZarspKaDkwd-w42st3F9XCAf21iYPE_oT54cETVqhvqe5fZ69f-I5eS-lesXtcCu5Ws3bDvlDTpGNKOr2TqdNg-GzpCVGWtHsuyLnGdaOnkJRax0iBfppnYA46OOjktZ7R4q3TNyFOB8aXZOCklaJCdsW3utSI4Hmy9vbG60b31B1tQH4VPoGXgPdUQU9PkYZCgipn0XwPMB5Wl8LnCMUa3VbKASKIQuFzTgUegxCKno8RAQ-QHtv7vcG3DxLMHxJKeSA_UdGFHhDSMJTFetEfKSPHZ5yFwDVz_5E9YkkrtbNa_IQbpMk2sCU8SCKp43dXENtI6xbdpWXDURbyQojXr9hpT2zXS7n31HTjWZR-lZJXKQfX0n93hcZ-ohl_Iv3IuOmQ
link.rule.ids 230,309,783,888,25578,76884
linkProvider European Patent Office
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3dT8IwEG8IGvFNUeMHahMNPi0CGx97IKZshU23sbQdIb4QykZCooPIjP--1wWUJ97aXnNpL7n2fu19IPQ478TJvGXGmqy1Tc2YSdC5xJDQbclObSrNpKGCk_2g5UTG67g5LqCPbSxMnif0J0-OCBo1A33P8vN69f-IZee-letnuYCh5UtfdO3qBh0DmlHVbO1el4ZDe2hVLasb8WrAcppuqOQlBLDSARjZHZVpn456Ki5ltXup9E_QYQj80uwUFZK0jErWtvZaGR35my9vaG60b32G1iTALCB4oIEdarMo9OgYc8EiS_kuYDfAIE_tcwFztHqjYWLCMcHCoYyENBKuhQVhAyowID9MvHeHuj5lTxzbLqeEU0wCG48Ic4cRx5aqWsP4OXroU2E5Gqx-8iesScR3t6pfoGK6TJNLhKeABWU8b6viGnA6xqZuGnFdB7yRAKxoNq9QZR-n6_3ke1RyhO9NPDd4u0HHipRH7BkVVMy-vpNbuLozeZdL_Be2FpGJ
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Apatent&rft.title=AN+RNA+G-QUADRUPLEX+STRUCTURE+IN+PRE-miRNA-1229+AS+A+THERAPEUTIC+TARGET+FOR+ALZHEIMER%27S+DISEASE+AND+VARIOUS+CANCERS&rft.inventor=Mihailescu%2C+Mihaela+Rita&rft.inventor=Imperatore%2C+Joshua+A&rft.date=2021-11-04&rft.externalDBID=A1&rft.externalDocID=US2021340537A1