DESIGN OF IMMUNOSTIMULATORY PROTEIN-CORE SPHERICAL NUCLEIC ACIDS

• Main Authors: Skakuj, Kacper, Hu, Xiaoyi S, Wang, Shuya, Mirkin, Chad A
• Format: Patent
• Language: English
• Published: 22.07.2021
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The disclosure is generally directed to immunostimulatory protein-core spherical nucleic acids (SNAs) comprising a protein core and a ratio of immunostimulatory and non-immunostimulatory strands, methods of making the immunostimulatory protein-core SNAs as well as their use.