6-AMINOPYRIDIN-3-YL THIAZOLES AS MODULATORS OF RORyT

The present invention comprises compounds of Formula I.wherein:A1, A2, A3, A4, A5, R1, and R2 are defined in the specification.The invention also comprises a method of treating or ameliorating a syndrome, disorder or disease, wherein the syndrome, disorder or disease is rheumatoid arthritis or psori...

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Main Authors Venkatesan, Hariharan, Goldberg, Steven, Martin, Connor L, Tanis, Virginia M, Xue, Xiaohua, Lebsack, Alec D, McClure, Kelly, Fennema, Elizabeth G, Woods, Craig R
Format Patent
LanguageEnglish
Published 01.07.2021
Subjects
APPARATUS THEREFOR
CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Abstract The present invention comprises compounds of Formula I.wherein:A1, A2, A3, A4, A5, R1, and R2 are defined in the specification.The invention also comprises a method of treating or ameliorating a syndrome, disorder or disease, wherein the syndrome, disorder or disease is rheumatoid arthritis or psoriasis. The invention also comprises a method of modulating RORγt activity in a mammal by administration of a therapeutically effective amount of at least one compound of Formula I.
AbstractList The present invention comprises compounds of Formula I.wherein:A1, A2, A3, A4, A5, R1, and R2 are defined in the specification.The invention also comprises a method of treating or ameliorating a syndrome, disorder or disease, wherein the syndrome, disorder or disease is rheumatoid arthritis or psoriasis. The invention also comprises a method of modulating RORγt activity in a mammal by administration of a therapeutically effective amount of at least one compound of Formula I.
Author Martin, Connor L
Fennema, Elizabeth G
Goldberg, Steven
Lebsack, Alec D
McClure, Kelly
Tanis, Virginia M
Xue, Xiaohua
Woods, Craig R
Venkatesan, Hariharan
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– fullname: Goldberg, Steven
– fullname: Martin, Connor L
– fullname: Tanis, Virginia M
– fullname: Xue, Xiaohua
– fullname: Lebsack, Alec D
– fullname: McClure, Kelly
– fullname: Fennema, Elizabeth G
– fullname: Woods, Craig R
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Snippet The present invention comprises compounds of Formula I.wherein:A1, A2, A3, A4, A5, R1, and R2 are defined in the specification.The invention also comprises a...
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SubjectTerms APPARATUS THEREFOR
CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
Title 6-AMINOPYRIDIN-3-YL THIAZOLES AS MODULATORS OF RORyT
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