CHK1 (SRA737)/PARPI COMBINATION METHODS OF INHIBITING TUMOR GROWTH
Herein disclosed are combinations of Checkpoint Kinase 1 (Chk1) inhibitors and PARP inhibitors useful for inhibiting the growth of tumors such as those in patients with cancer. In particular, the combination demonstrates remarkable synergistic effects on cancer cells that are representative models f...
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| Main Authors | , , , |
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| Format | Patent |
| Language | English |
| Published |
18.03.2021
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| Subjects | |
| Online Access | Get full text |
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| Abstract | Herein disclosed are combinations of Checkpoint Kinase 1 (Chk1) inhibitors and PARP inhibitors useful for inhibiting the growth of tumors such as those in patients with cancer. In particular, the combination demonstrates remarkable synergistic effects on cancer cells that are representative models for tumors. Also provided for are methods for treating disorders or diseases mediated or affected by Chk1 and/or PARP activity. |
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| AbstractList | Herein disclosed are combinations of Checkpoint Kinase 1 (Chk1) inhibitors and PARP inhibitors useful for inhibiting the growth of tumors such as those in patients with cancer. In particular, the combination demonstrates remarkable synergistic effects on cancer cells that are representative models for tumors. Also provided for are methods for treating disorders or diseases mediated or affected by Chk1 and/or PARP activity. |
| Author | HASSIG, Christian Andrew ANDERES, Kenna Lynn STROUSE, Bryan William HANSEN, Ryan James |
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| Notes | Application Number: US201816604116 |
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| RelatedCompanies | SIERRA ONCOLOGY, INC |
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| Snippet | Herein disclosed are combinations of Checkpoint Kinase 1 (Chk1) inhibitors and PARP inhibitors useful for inhibiting the growth of tumors such as those in... |
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| Title | CHK1 (SRA737)/PARPI COMBINATION METHODS OF INHIBITING TUMOR GROWTH |
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