ANTIBODY PROTAC CONJUGATES

An immunoconjugate having the Formula Ab-[L1-(A-L2-B)m]n, wherein: (a) Ab is an antibody or a binding fragment thereof; (b) L1 and L2 are each independently a linker, wherein L1 and L2 are the same or different and wherein L1 links to L2; (c) A is a target-protein ligand/binder; (d) B is a ubiquitin...

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Bibliographic Details
Main Authors Lin, Her-Sheng, Lin, Wun-Huei, Lai, Chun-Liang, Chuang, Shih-Hsien, Liao, Chu-Bin, Liang, Chen-Hsien, Sun, Wei-Ting
Format Patent
LanguageEnglish
Published 21.01.2021
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Summary:An immunoconjugate having the Formula Ab-[L1-(A-L2-B)m]n, wherein: (a) Ab is an antibody or a binding fragment thereof; (b) L1 and L2 are each independently a linker, wherein L1 and L2 are the same or different and wherein L1 links to L2; (c) A is a target-protein ligand/binder; (d) B is a ubiquitin ligase ligand/binder, and (e) n and m are independently integers from 1 to 8. The target protein includes kinase, G protein-coupled receptors, transcription factor, phosphatases, and RAS superfamily members.
Bibliography:Application Number: US201916244090