FRAGMENT SYNTHESIS OF CYCLIC PEPTIDES

• Main Authors: KAFAL, Adam Paul, POUPART, Marc-André, VAZQUEZ, Manuel Perez, HICKEY, Jennifer L, ROUGHTON, Andrew L, MORSHED, M. Monzur, GILLARD, James, YANG, Gaoqiang
• Format: Patent
• Language: English
• Published: 19.11.2020
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

There is described herein antagonists of α4β7 integrin, and more particularly to cyclic peptide antagonists. Accordingly, there is described herein a compound of formula (I) wherein R1, R2, R3, R4, R5, R6, R7 and R8 are various substituents; stereocentres 1*, 2* and 3* are each independently selecte...