FRAGMENT SYNTHESIS OF CYCLIC PEPTIDES
There is described herein antagonists of α4β7 integrin, and more particularly to cyclic peptide antagonists. Accordingly, there is described herein a compound of formula (I) wherein R1, R2, R3, R4, R5, R6, R7 and R8 are various substituents; stereocentres 1*, 2* and 3* are each independently selecte...
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| Main Authors | , , , , , , , |
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| Format | Patent |
| Language | English |
| Published |
19.11.2020
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| Subjects | |
| Online Access | Get full text |
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| Abstract | There is described herein antagonists of α4β7 integrin, and more particularly to cyclic peptide antagonists. Accordingly, there is described herein a compound of formula (I) wherein R1, R2, R3, R4, R5, R6, R7 and R8 are various substituents; stereocentres 1*, 2* and 3* are each independently selected from R and S; n is 1, 2, 3, or 4 and where n is 2-4, Z is an amino terminus of an amino acid; -C═O- adjacent L is the carboxy terminus of an amino acid; and L along with Z and -C═O- is a peptide. |
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| AbstractList | There is described herein antagonists of α4β7 integrin, and more particularly to cyclic peptide antagonists. Accordingly, there is described herein a compound of formula (I) wherein R1, R2, R3, R4, R5, R6, R7 and R8 are various substituents; stereocentres 1*, 2* and 3* are each independently selected from R and S; n is 1, 2, 3, or 4 and where n is 2-4, Z is an amino terminus of an amino acid; -C═O- adjacent L is the carboxy terminus of an amino acid; and L along with Z and -C═O- is a peptide. |
| Author | HICKEY, Jennifer L POUPART, Marc-André ROUGHTON, Andrew L VAZQUEZ, Manuel Perez KAFAL, Adam Paul YANG, Gaoqiang MORSHED, M. Monzur GILLARD, James |
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| Notes | Application Number: US202016985096 |
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| RelatedCompanies | Encycle Therapeutics, Inc Universite de Montreal |
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| Snippet | There is described herein antagonists of α4β7 integrin, and more particularly to cyclic peptide antagonists. Accordingly, there is described herein a compound... |
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| SubjectTerms | ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| Title | FRAGMENT SYNTHESIS OF CYCLIC PEPTIDES |
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