ISOQUINOLIN-3-YL CARBOXAMIDES AND PREPARATION AND USE THEREOF

Isoquinoline compounds for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of an isoquinoline compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal...

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Main Authors KC, Sunil Kumar, Cao, Jianguo, Chiruta, Chandramouli, Eastman, Brian Walter, Bollu, Venkataiah, Mittapalli, Gopi Kumar, Mak, Chi Ching
Format Patent
LanguageEnglish
Published 24.09.2020
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Abstract Isoquinoline compounds for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of an isoquinoline compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, fibrotic disorders, bone or cartilage diseases, and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as genetic diseases and neurological conditions/disorders/diseases due to mutations or dysregulation of the Wnt pathway and/or of one or more of Wnt signaling components. Also provided are methods for treating Wnt-related disease states.
AbstractList Isoquinoline compounds for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of an isoquinoline compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, fibrotic disorders, bone or cartilage diseases, and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as genetic diseases and neurological conditions/disorders/diseases due to mutations or dysregulation of the Wnt pathway and/or of one or more of Wnt signaling components. Also provided are methods for treating Wnt-related disease states.
Author Eastman, Brian Walter
Bollu, Venkataiah
Chiruta, Chandramouli
Mak, Chi Ching
Mittapalli, Gopi Kumar
Cao, Jianguo
KC, Sunil Kumar
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– fullname: Mittapalli, Gopi Kumar
– fullname: Mak, Chi Ching
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Snippet Isoquinoline compounds for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of an...
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HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
Title ISOQUINOLIN-3-YL CARBOXAMIDES AND PREPARATION AND USE THEREOF
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