Antibody Drug Conjugates with Cell Permeable BCL-XL Inhibitors

• Main Authors: Sullivan, Gerard M, Judd, Andrew S, Bruncko, Milan, Kunzer, Aaron R, Doherty, George, Wang, Xilu, Welch, Dennle S, Marin, Violeta L, Song, Xiaohong, Tao, Zhi-fu, Boghaert, Erwin R, Ackler, Scott L, Souers, Andrew J
• Format: Patent
• Language: English
• Published: 06.08.2020
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

Small molecule Bcl-xL inhibitors and Antibody Drug Conjugates (ADCs) comprising small molecule Bcl-xL inhibitors are disclosed herein. The Bcl-xL inhibitors and ADCs of the disclosure are useful for, among other things, inhibiting anti-apoptotic Bcl-xL proteins as a therapeutic approach towards the...