Consensus Coding Sequences of Human Breast and Colorectal Cancers

• Main Authors: VELCULESCU, Victor E, VOGELSTEIN, Bert, KINZLER, Kenneth W, PARSONS, D. Williams, LIN, Jimmy Cheng-Ho, BARBER, Thomas, SJOBLOM, Tobias, JONES, Sian, MANDELKER, Diana, WOOD, Laura D
• Format: Patent
• Language: English
• Published: 30.07.2020
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; ENZYMOLOGY; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; PROCESSES OF PREPARING SUCH COMPOSITIONS; SPIRITS; VINEGAR; WINE

Analysis of 13,023 genes in 11 breast and 11 colorectal cancers revealed that individual tumors accumulate an average of ˜90 mutant genes but that only a subset of these contribute to the neoplastic process. Using stringent criteria to delineate this subset, we identified 189 genes (average of 11 pe...