PROCESS FOR THE PREPARATION OF FLUTICASONE PROPIONATE FORM I

The invention relates to a novel crystallisation process for preparing fluticasone propionate as crystalline form 1 polymorph with controlled particle size and suitable for micronisation. Said process comprises the step of dissolving fluticasone propionate in acetone or in a mixture of acetone and w...

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Bibliographic Details
Main Authors Kougoulos, Eleftherios, Ticehurst, Martyn David, Marziano, Ivan
Format Patent
LanguageEnglish
Published 23.01.2020
Subjects
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
STEROIDS
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Summary:The invention relates to a novel crystallisation process for preparing fluticasone propionate as crystalline form 1 polymorph with controlled particle size and suitable for micronisation. Said process comprises the step of dissolving fluticasone propionate in acetone or in a mixture of acetone and water and then adding this solution to water or to a mixture of water 10 and acetone, thereby causing fluticasone propionate to crystallise out of the solution as crystalline form.
Bibliography:Application Number: US201916525111