SUBSTITUTED AMINO TRIAZOLES USEFUL AS HUMAN CHITINASE INHIBITORS

Disclosed are amino triazole compounds substituted with a piperidinyl ring that is itself substituted with a heterocyclic ring. These compounds are inhibitors of acidic mammalian chitinase and chitotriosidase. Also disclosed are methods of using the compounds to treat asthma reactions caused by alle...

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Main Authors Koralewski, Robert, Olejniczak, Sylwia, Czestkowski, Wojciech J, Maziarz, Elzbieta, Kowalski, Michal L, Piotrowicz, Michal C, Olczak, Jacek P, Mazur, Marzena, Golebiowski, Adam A, Borek, Bartlomiej, Bartoszewicz, Agnieszka
Format Patent
LanguageEnglish
Published 14.11.2019
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Abstract Disclosed are amino triazole compounds substituted with a piperidinyl ring that is itself substituted with a heterocyclic ring. These compounds are inhibitors of acidic mammalian chitinase and chitotriosidase. Also disclosed are methods of using the compounds to treat asthma reactions caused by allergens, as well as acute and chronic inflammatory diseases, autoimmune diseases, dental diseases, neurologic diseases, metabolic diseases, liver diseases, polycystic ovary syndrome, endometriosis, and cancer.
AbstractList Disclosed are amino triazole compounds substituted with a piperidinyl ring that is itself substituted with a heterocyclic ring. These compounds are inhibitors of acidic mammalian chitinase and chitotriosidase. Also disclosed are methods of using the compounds to treat asthma reactions caused by allergens, as well as acute and chronic inflammatory diseases, autoimmune diseases, dental diseases, neurologic diseases, metabolic diseases, liver diseases, polycystic ovary syndrome, endometriosis, and cancer.
Author Golebiowski, Adam A
Kowalski, Michal L
Olczak, Jacek P
Bartoszewicz, Agnieszka
Borek, Bartlomiej
Mazur, Marzena
Koralewski, Robert
Czestkowski, Wojciech J
Maziarz, Elzbieta
Olejniczak, Sylwia
Piotrowicz, Michal C
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– fullname: Maziarz, Elzbieta
– fullname: Kowalski, Michal L
– fullname: Piotrowicz, Michal C
– fullname: Olczak, Jacek P
– fullname: Mazur, Marzena
– fullname: Golebiowski, Adam A
– fullname: Borek, Bartlomiej
– fullname: Bartoszewicz, Agnieszka
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Snippet Disclosed are amino triazole compounds substituted with a piperidinyl ring that is itself substituted with a heterocyclic ring. These compounds are inhibitors...
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SubjectTerms CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
Title SUBSTITUTED AMINO TRIAZOLES USEFUL AS HUMAN CHITINASE INHIBITORS
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