INSULIN GENE-DERIVED PROTEINS AND PEPTIDES FOR USE IN THE DIAGNOSIS AND TREATMENT OF TYPE 1 DIABETES
The present invention relates to the identification of novel peptides derived from aberrant proteins involved in Type 1 Diabetes mellitus (T1D), also known as defective ribosomal products (DRiPs). In particular the invention relates to epitopes present in DRiPs of the human preproinsulin (PPI) mRNA,...
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Format | Patent |
Language | English |
Published |
31.10.2019
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Abstract | The present invention relates to the identification of novel peptides derived from aberrant proteins involved in Type 1 Diabetes mellitus (T1D), also known as defective ribosomal products (DRiPs). In particular the invention relates to epitopes present in DRiPs of the human preproinsulin (PPI) mRNA, its representative peptides and the use thereof in diagnosis, prevention and/or treatment of T1D. Moreover, the inventions relate to antibodies and antisera against the identified epitopes and the use thereof in the diagnosis of T1D. |
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AbstractList | The present invention relates to the identification of novel peptides derived from aberrant proteins involved in Type 1 Diabetes mellitus (T1D), also known as defective ribosomal products (DRiPs). In particular the invention relates to epitopes present in DRiPs of the human preproinsulin (PPI) mRNA, its representative peptides and the use thereof in diagnosis, prevention and/or treatment of T1D. Moreover, the inventions relate to antibodies and antisera against the identified epitopes and the use thereof in the diagnosis of T1D. |
Author | VAN VEELEN, Peter Antonis ROEP, Bart Otto VAN LUMMEL, Menno ZALDUMBIDE, Arnaud |
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Snippet | The present invention relates to the identification of novel peptides derived from aberrant proteins involved in Type 1 Diabetes mellitus (T1D), also known as... |
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Title | INSULIN GENE-DERIVED PROTEINS AND PEPTIDES FOR USE IN THE DIAGNOSIS AND TREATMENT OF TYPE 1 DIABETES |
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