PROTOCELLS TO TREAT MICROBIAL INFECTION AND FOR SYNERGISTIC DELIVERY
The present disclosure relates to protocells that are useful in the treatment and prevention of viral infections, including but not limited to infections caused by a Hendra virus and Nipah virus (NiV). The present disclosure relates to protocells that are useful in the treatment of bacterial infecti...
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| Main Authors | , , , , , , |
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| Format | Patent |
| Language | English |
| Published |
29.08.2019
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| Subjects | |
| Online Access | Get full text |
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| Abstract | The present disclosure relates to protocells that are useful in the treatment and prevention of viral infections, including but not limited to infections caused by a Hendra virus and Nipah virus (NiV). The present disclosure relates to protocells that are useful in the treatment of bacterial infections, including antibiotic-resistant bacterial infections. The protocells are coated with a lipid bi- or multilayer comprising at least one moiety that targets a viral cellular receptor and at least one moiety that ruptures a virally-infected cell membrane. The present disclosure further relates to novel mesoporous metal oxide nanoparticles and related protocells that are useful in the treatment and/or prevention of a wide variety of disorders, including a cancer or a bacterial or viral infection. Such nanoparticles and protocells can be functionalized to allow for synergistic loading of a wide variety of active ingredients. |
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| AbstractList | The present disclosure relates to protocells that are useful in the treatment and prevention of viral infections, including but not limited to infections caused by a Hendra virus and Nipah virus (NiV). The present disclosure relates to protocells that are useful in the treatment of bacterial infections, including antibiotic-resistant bacterial infections. The protocells are coated with a lipid bi- or multilayer comprising at least one moiety that targets a viral cellular receptor and at least one moiety that ruptures a virally-infected cell membrane. The present disclosure further relates to novel mesoporous metal oxide nanoparticles and related protocells that are useful in the treatment and/or prevention of a wide variety of disorders, including a cancer or a bacterial or viral infection. Such nanoparticles and protocells can be functionalized to allow for synergistic loading of a wide variety of active ingredients. |
| Author | Wilkinson, Brian S Brinker, C. Jeffrey Carnes, Eric C Ashley, Carlee Erin Padilla, David Patrick Negrete, Oscar Wilkinson, Dan C |
| Author_xml | – fullname: Wilkinson, Dan C – fullname: Wilkinson, Brian S – fullname: Carnes, Eric C – fullname: Brinker, C. Jeffrey – fullname: Ashley, Carlee Erin – fullname: Negrete, Oscar – fullname: Padilla, David Patrick |
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| RelatedCompanies | Wilkinson Dan C Brinker C. Jeffrey Wilkinson Brian S Carnes Eric C Negrete Oscar Padilla David Patrick Ashley Carlee Erin |
| RelatedCompanies_xml | – name: Ashley Carlee Erin – name: Negrete Oscar – name: Padilla David Patrick – name: Brinker C. Jeffrey – name: Wilkinson Brian S – name: Carnes Eric C – name: Wilkinson Dan C |
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| Snippet | The present disclosure relates to protocells that are useful in the treatment and prevention of viral infections, including but not limited to infections... |
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| Title | PROTOCELLS TO TREAT MICROBIAL INFECTION AND FOR SYNERGISTIC DELIVERY |
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