ANTIBODIES WITH REDUCED BINDING TO PROCESS IMPURITIES

The present invention relates to variant antibodies and methods of generating said antibodies with a reduced level of binding to process impurities. In particular, the invention describes variant IgG4 antibodies which have been modified in the heavy chain constant region at any one or a combination...

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Main Authors THOMSON, Andrew S, BOSTEELS, Hella, KUCIA-TRAN, Richard, FARROW, Kayeleigh, LEWIS, William John Kenneth, UDEN, Mark, CHEN, Shugui
Format Patent
LanguageEnglish
Published 25.07.2019
Subjects
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Abstract The present invention relates to variant antibodies and methods of generating said antibodies with a reduced level of binding to process impurities. In particular, the invention describes variant IgG4 antibodies which have been modified in the heavy chain constant region at any one or a combination of amino acids in the region between Kabat residues 203 and 256, wherein the variant IgG4 antibody has a reduced level of binding to host cell protein (HCP), compared to an unmodified IgG4 antibody. The invention also relates to compositions comprising said variant IgG4 antibodies.
AbstractList The present invention relates to variant antibodies and methods of generating said antibodies with a reduced level of binding to process impurities. In particular, the invention describes variant IgG4 antibodies which have been modified in the heavy chain constant region at any one or a combination of amino acids in the region between Kabat residues 203 and 256, wherein the variant IgG4 antibody has a reduced level of binding to host cell protein (HCP), compared to an unmodified IgG4 antibody. The invention also relates to compositions comprising said variant IgG4 antibodies.
Author LEWIS, William John Kenneth
KUCIA-TRAN, Richard
BOSTEELS, Hella
THOMSON, Andrew S
UDEN, Mark
FARROW, Kayeleigh
CHEN, Shugui
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– fullname: FARROW, Kayeleigh
– fullname: LEWIS, William John Kenneth
– fullname: UDEN, Mark
– fullname: CHEN, Shugui
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Snippet The present invention relates to variant antibodies and methods of generating said antibodies with a reduced level of binding to process impurities. In...
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SubjectTerms CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
Title ANTIBODIES WITH REDUCED BINDING TO PROCESS IMPURITIES
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