DIOXOLANE ANALOGUES OF URIDINE FOR THE TREATMENT OF CANCER

The invention provides compounds of the formula:R1is OR11, or NR5R5';R2is F;R5is H, C1-C6alkyl, OH, C(=O)R6, O(C=O)R6or O(C=O)OR6;R5'is H or C1-C6alkyl;R6is C1-C22alkyl or C3-C7cycloalkyl;R13is H, phenyl, pyridyl, benzyl, indolyl or naphthyl wherein the phenyl, pyridyl, benzyl, indolyl and...

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Bibliographic Details
Main Authors BETHELL, Richard, ENEROTH, Anders, KLASSON, Bjorn, OBERG, Fredrik
Format Patent
LanguageEnglish
Published 04.04.2019
Subjects
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The invention provides compounds of the formula:R1is OR11, or NR5R5';R2is F;R5is H, C1-C6alkyl, OH, C(=O)R6, O(C=O)R6or O(C=O)OR6;R5'is H or C1-C6alkyl;R6is C1-C22alkyl or C3-C7cycloalkyl;R13is H, phenyl, pyridyl, benzyl, indolyl or naphthyl wherein the phenyl, pyridyl, benzyl, indolyl and naphthyl is optionally substituted with 1, 2 or 3 R22;and the other variables are as defined in the claims,which are of use in the treatment of cancer, and related aspects.
Bibliography:Application Number: US201816208083