INSULIN-LIKE GROWTH FACTOR 2 (IGF2) BINDING AGENTS
This invention relates to mutant polypeptides comprising the IGF2 binding domain of the Insulin-like Growth Factor 2 Receptor (IGF2R) with residue P1597 is substituted for a different residue, for example H or K. Other residues which may be mutated include S1543, E1544, K1545, G1546, L1547, Q1569, S...
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| Main Authors | , |
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| Format | Patent |
| Language | English |
| Published |
23.08.2018
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| Subjects | |
| Online Access | Get full text |
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| Abstract | This invention relates to mutant polypeptides comprising the IGF2 binding domain of the Insulin-like Growth Factor 2 Receptor (IGF2R) with residue P1597 is substituted for a different residue, for example H or K. Other residues which may be mutated include S1543, E1544, K1545, G1546, L1547, Q1569, S1602, G1603 and/or K1631. These IGF2 binding domains display dramatically increased binding affinity for IGF2 compared to both the wild-type and previously identified mutants and may be useful for example in cancer therapy. |
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| AbstractList | This invention relates to mutant polypeptides comprising the IGF2 binding domain of the Insulin-like Growth Factor 2 Receptor (IGF2R) with residue P1597 is substituted for a different residue, for example H or K. Other residues which may be mutated include S1543, E1544, K1545, G1546, L1547, Q1569, S1602, G1603 and/or K1631. These IGF2 binding domains display dramatically increased binding affinity for IGF2 compared to both the wild-type and previously identified mutants and may be useful for example in cancer therapy. |
| Author | Crump, Matthew Philip Hassan, Andrew Bassim |
| Author_xml | – fullname: Crump, Matthew Philip – fullname: Hassan, Andrew Bassim |
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| RelatedCompanies | Cancer Research Technology Limited |
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| Snippet | This invention relates to mutant polypeptides comprising the IGF2 binding domain of the Insulin-like Growth Factor 2 Receptor (IGF2R) with residue P1597 is... |
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| Title | INSULIN-LIKE GROWTH FACTOR 2 (IGF2) BINDING AGENTS |
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