SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS

• Main Authors: OALMANN Christopher, BLUM Charles A, DISCH Jeremy S, SZCZEPANKIEWICZ Bruce G, WHITE Brian H, PERNI Robert B, CALDWELL Richard Dana, FOX Ryan Michael, CASAUBON Rebecca, KOPPETSCH Karsten, NG Pui Yee
• Format: Patent
• Language: English
• Published: 15.02.2018
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

Provided herein are novel substituted bridged urea and related analogs and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders...