SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS

Provided herein are novel substituted bridged urea and related analogs and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders...

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Main Authors OALMANN Christopher, BLUM Charles A, DISCH Jeremy S, SZCZEPANKIEWICZ Bruce G, WHITE Brian H, PERNI Robert B, CALDWELL Richard Dana, FOX Ryan Michael, CASAUBON Rebecca, KOPPETSCH Karsten, NG Pui Yee
Format Patent
LanguageEnglish
Published 15.02.2018
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Abstract Provided herein are novel substituted bridged urea and related analogs and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.
AbstractList Provided herein are novel substituted bridged urea and related analogs and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.
Author CALDWELL Richard Dana
SZCZEPANKIEWICZ Bruce G
PERNI Robert B
BLUM Charles A
KOPPETSCH Karsten
NG Pui Yee
WHITE Brian H
CASAUBON Rebecca
FOX Ryan Michael
DISCH Jeremy S
OALMANN Christopher
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– fullname: CALDWELL Richard Dana
– fullname: FOX Ryan Michael
– fullname: CASAUBON Rebecca
– fullname: KOPPETSCH Karsten
– fullname: NG Pui Yee
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Snippet Provided herein are novel substituted bridged urea and related analogs and methods of use thereof. The sirtuin-modulating compounds may be used for increasing...
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SubjectTerms CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Title SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS
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