INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL

• Main Authors: Jiang Jinlong, Ferguson, II Ronald, Blizzard Timothy A, Shi Zhi-Cai, Suzuki Takao, Pasternak Alexander, Wu Zhicai, Yu Yang, Guo Zhiqiang, Gu Xin, Frie Jessica, Vangelder Kelsey F, Walsh Shawn P, Dong Shuzhi, Fu Qinghong
• Format: Patent
• Language: English
• Published: 28.09.2017
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

The present invention provides compounds of Formula I and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascul...